Joseph C. Irwin
- 1940 – New Jersey’s 3rd congressional district (R) – lost
Mitch Irwin
- 1988 – Michigan’s 11th congressional district (D) – lost
Shirley Irwin
- 1972 – Alabama’s 5th congressional district (Nat. Dem.) – lost
David Isaac
- 1980 – Michigan’s 10th congressional district (AI) – lost
Shirley Rachel Isaacson
- 1986 – California’s 44th congressional district (PF) – lost
- 1988 – California’s 22nd congressional district (PF) – lost
Steve Isaacson
- 2016 – Arkansas’ 3rd congressional district (L) – lost
Charlie Isaak
- 1978 – Hawaii’s 2nd congressional district (R) – lost
Leo Isacson
- 1948 – New York’s 24th congressional district (American Labor) – lost
John Hardy Isakson
- 2000 – Georgia’s 6th congressional district (R) – won
- 2002 – Georgia’s 6th congressional district (R) – won
- 2004 – United States Senate (Georgia) (R) – won
- 2010 – United States Senate (Georgia) (R) – won
- 2016 – United States Senate (Georgia) (R) – won
John B. Isbell
- 1930 – Alabama’s 7th congressional district (R) – lost
A. Isenberg
- 1932 – Tennessee’s 1st congressional district (I) – lost
Thomas W. Isenhour
- 1996 – Iowa’s 1st congressional district (Nomination by Petition) – lost
Charles M. Isenhower
- 1964 – Texas’ 11th congressional district (R) – lost
Arthur E. Isham
- 1942 – California’s 21st congressional district (W/I) – lost
Larry Ishmael
- 2006 – Washington’s 1st congressional district (R) – lost
- 2008 – Washington’s 1st congressional district (R) – lost
Tabitha Isner
- 2018 – Alabama’s 2nd congressional district (D) – lost
David D. Israel
- 1922 – Missouri’s 12th congressional district (D) – lost
- 1926 – Missouri’s 12th congressional district (D) – lost
Steven J. Israel
- 2000 – New York’s 2nd congressional district (D) – won
- 2002 – New York’s 2nd congressional district (D, IND, WF) – won
- 2004 – New York’s 2nd congressional district (D, IND, WF) – won
- 2006 – New York’s 2nd congressional district (D, IND, WF) – won
- 2008 – New York’s 2nd congressional district (D, IND, WF) – won
- 2010 – New York’s 2nd congressional district (D) – won
- 2012 – New York’s 3rd congressional district (D, WF, IND) – won
- 2014 – New York’s 3rd congressional district (D, WF, IND) – won
Darrell Edward Issa
- 2000 – California’s 48th congressional district (R) – won
- 2002 – California’s 49th congressional district (R) – won
- 2004 – California’s 49th congressional district (R) – won
- 2006 – California’s 49th congressional district (R) – won
- 2008 – California’s 49th congressional district (R) – won
- 2010 – California’s 49th congressional district (R) – won
- 2012 – California’s 49th congressional district (R) – won
- 2014 – California’s 49th congressional district (R) – won
- 2016 – California’s 49th congressional district (R) – won
- 2020 – California’s 50th congressional district (R) – won
- 2022 – California’s 48th congressional district (R) – won
Richard Ista
- 1972 – North Dakota’s at large congressional district (D) – lost
Ernest James Istook, Jr.
- 1992 – Oklahoma’s 5th congressional district (R) – won
- 1994 – Oklahoma’s 5th congressional district (R) – won
- 1996 – Oklahoma’s 5th congressional district (R) – won
- 1998 – Oklahoma’s 5th congressional district (R) – won
- 2000 – Oklahoma’s 5th congressional district (R) – won
- 2002 – Oklahoma’s 5th congressional district (R) – won
- 2004 – Oklahoma’s 5th congressional district (R) – won
Michael Italie
- 2002 – Florida’s 17th congressional district (W/I) – lost
Mikhail Itkis
- 2022 – New York’s 12th congressional district (Itkis Campaign) – lost
Boaz Itshaky
- 2008 – Connecticut’s 3rd congressional district (R) – lost
- 2010 – Connecticut’s 3rd congressional district (W/I) – lost
Nicholas J. Ivanovich
- 2010 – Missouri’s 3rd congressional district (C) – lost
G. D. Iverson Jr.
- 1920 – United States Senate (Maryland) (I) – lost
Robert B. Iverson
- 1996 – Ohio’s 10th congressional district (NL) – lost
Stan Iverson
- 1970 – Washington’s 1st congressional district (I) – lost
Irving McNeil Ives
- 1946 – United States Senate (New York) (R) – won
- 1952 – United States Senate (New York) (R) – won
E. Ralph Ivey
- 1960 – Georgia’s 7th congressional district (R) – lost
- 1962 – Georgia’s 7th congressional district (R) – lost
Glenn Frederick Ivey
- 2022 – Maryland’s 4th congressional district (D) – won
Mark Ivey, Jr.
- 1990 – Arizona’s 4th congressional district (D) – lost
H. B. Ivey
- 1932 – North Carolina’s 3rd congressional district (R) – lost
Melinda Ivey
- 2006 – Missouri’s 4th congressional district (Prog.) – lost
William P. Ivey
- 1948 – Alabama’s 6th congressional district (R) – lost
- 1960 – Alabama’s 9th congressional district (R) – lost
Jean Ivory
- 1952 – New York’s 37th congressional district (D, Liberal) – lost
Nathaniel Ivory
- 1990 – Alabama’s 6th congressional district (I) – lost
Dan Ivy
- 1990 – Arkansas’ 3rd congressional district (D) – lost
- 1996 – Arkansas’ 3rd congressional district (W/I) – lost
David Iwancio
- 2002 – Louisiana’s 3rd congressional district (Other) – lost
Edouard Victor Michel Izac
- 1934 – California’s 20th congressional district (D, Prog.) – lost
- 1936 – California’s 20th congressional district (D) – won
- 1938 – California’s 20th congressional district (D) – won
- 1940 – California’s 20th congressional district (D) – won
- 1942 – California’s 23rd congressional district (D) – won
- 1944 – California’s 23rd congressional district (D) – won
- 1946 – California’s 23rd congressional district (D) – lost
Rudy Izzard
- 1996 – Texas’ 17th congressional district (R) – lost
- 1998 – Texas’ 17th congressional district (R) – lost
Rose Izzo
- 2014 – Delaware’s at large congressional district (R) – lost
