Francis C. Sperry
- 1948 – Illinois’ 7th congressional district (R) – lost
John A. Speziale
- 1952 – Connecticut’s 5th congressional district (D) – lost
Keith Spicer
- 1984 – Minnesota’s 1st congressional district (R) – lost
Lavern Spicer
- 2020 – Florida’s 24th congressional district (R) – lost
William S. Spicer
- 1956 – Arkansas’ 3rd congressional district (R) – lost
Andrew B. Spiegel
- 1992 – United States Senate (Illinois) (L) – lost
George A. Spiegelberg
- 1934 – New York’s 17th congressional district (R) – lost
Lee Arnold Spiegelman
- 1976 – Florida’s 13th congressional district (R) – lost
William Spiers
- 1982 – Michigan’s 10th congressional district (L) – lost
William D. Spillane
- 1978 – Hawaii’s 1st congressional district (R) – lost
C. Lee Spillers
- 1956 – West Virginia’s 1st congressional district (D) – lost
Bill Spingler
- 1986 – Pennsylvania’s 7th congressional district (D) – lost
Chuck Spingola
- 2004 – Ohio’s 12th congressional district (W/I) – lost
Frank C. Spinner
- 1968 – New York’s 15th congressional district (R) – lost
- 1970 – New York’s 15th congressional district (R) – lost
Elvington P. Spinney
- 1928 – Maine’s 1st congressional district (D) – lost
John C. Spinney
- 1936 – New Hampshire’s 2nd congressional district (FL) – lost
James E. Spinosa
- 2000 – New Jersey’s 11th congressional district (I) – lost
Stephen Spinosa
- 1998 – New Jersey’s 8th congressional district (I) – lost
Tom Spinosa
- 1974 – California’s 6th congressional district (R) – lost
- 1976 – California’s 6th congressional district (R) – lost
- 1978 – California’s 6th congressional district (R) – lost
- 1980 – California’s 6th congressional district (R) – lost
- 1983 – California’s 5th congressional district (Special) (R) – lost
- 1984 – California’s 5th congressional district (R) – lost
Ona Spiridellis
- 1992 – New Jersey’s 11th congressional district (D) – lost
Herbert John Spiro
- 1992 – Texas’ 10th congressional district (R) – lost
Dennis Spisak
- 2008 – Ohio’s 6th congressional district (G) – lost
Merrill Spitler
- 1942 – Missouri’s 10th congressional district (R) – lost
Herman Spittal
- 1920 – Pennsylvania’s at large congressional district (Indus.) – lost
Alan Spitz
- 1998 – Illinois’ 5th congressional district (R) – lost
Henry H. Spitz
- 1928 – New York’s 23rd congressional district (R) – lost
Linda Spitzfaden
- 1992 – New Hampshire’s 1st congressional district (NL) – lost
- 1994 – New Hampshire’s 2nd congressional district (NL) – lost
Abraham M. Spivack
- 1934 – Connecticut’s 4th congressional district (Comm.) – lost
Dennis Spivack
- 2006 – Delaware’s at large congressional district (D) – lost
Ira Spivack
- 2002 – California’s 8th congressional district (L) – lost
William Belser Spong, Jr.
- 1966 – United States Senate (Virginia) (Special) (D) – won
- 1972 – United States Senate (Virginia) (D) – lost
Jim Spoo
- 1988 – Nevada’s 2nd congressional district (D) – lost
Jeffrey Wayne Spoonamore
- 2010 – Indiana’s 7th congressional district (W/I) – lost
Frank Spooner
- 1976 – Louisiana’s 5th congressional district (R) – lost
Charles H. Sporkin
- 1954 – Pennsylvania’s 3rd congressional district (R) – lost
- 1956 – Pennsylvania’s 3rd congressional district (R) – lost
Frank J. Spotorno
- 2016 – New York’s 14th congressional district (R, CON) – lost
Lydia C. Spottswood
- 1996 – Wisconsin’s 1st congressional district (D) – lost
Lydia Carol Spottswood
- 1998 – Wisconsin’s 1st congressional district (D) – lost
Albert A. Sprague
- 1924 – United States Senate (Illinois) (D) – lost
Albert P. Sprague
- 1920 – Nebraska’s 4th congressional district (D) – lost
David Sprague
- 1986 – Colorado’s 4th congressional district (D) – lost
George Sprague
- 1972 – Wisconsin’s 5th congressional district (American) – lost
Howard Lee Sprague
- 1994 – Arizona’s 3rd congressional district (D) – lost
Hugh A. Sprague
- 1970 – Missouri’s 6th congressional district (R) – lost
Marshall Sprague
- 1982 – North Carolina’s 3rd congressional district (L) – lost
Peter J. Sprague
- 1970 – New York’s 17th congressional district (R) – lost
Philip A. Sprague
- 1970 – Indiana’s 2nd congressional district (D) – lost
Robert Sprague
- 1938 – Wisconsin’s 4th congressional district (Union) – lost
Stephen R. Sprague
- 2010 – Tennessee’s 6th congressional district (I) – lost
John McKee Spratt, Jr.
- 1982 – South Carolina’s 5th congressional district (D) – won
- 1984 – South Carolina’s 5th congressional district (D) – won
- 1986 – South Carolina’s 5th congressional district (D) – won
- 1988 – South Carolina’s 5th congressional district (D) – won
- 1990 – South Carolina’s 5th congressional district (D) – won
- 1992 – South Carolina’s 5th congressional district (D) – won
- 1994 – South Carolina’s 5th congressional district (D) – won
- 1996 – South Carolina’s 5th congressional district (D) – won
- 1998 – South Carolina’s 5th congressional district (D) – won
- 2000 – South Carolina’s 5th congressional district (D) – won
- 2002 – South Carolina’s 5th congressional district (D) – won
- 2004 – South Carolina’s 5th congressional district (D) – won
- 2006 – South Carolina’s 5th congressional district (D) – won
- 2008 – South Carolina’s 5th congressional district (D) – won
- 2010 – South Carolina’s 5th congressional district (D) – lost