Zachary T. Space
- 2006 – Ohio’s 18th congressional district (D) – won
- 2008 – Ohio’s 18th congressional district (D) – won
- 2010 – Ohio’s 18th congressional district (D) – lost
Thomas O. Spacey
- 1924 – Colorado’s 1st congressional district (I) – lost
Anthony Spadafora
- 1934 – New York’s 33rd congressional district (S) – lost
Michael J. Spadaro
- 1966 – New York’s 13th congressional district (CON) – lost
William G. Spadea
- 2004 – New Jersey’s 12th congressional district (R) – lost
Hans A. Spading
- 1946 – Illinois’ 16th congressional district (D) – lost
Carl P. Spaeth
- 1938 – Virginia’s 2nd congressional district (I) – lost
Edward E. Spafford
- 1930 – New York’s 14th congressional district (R) – lost
Carla Spalding
- 2022 – Florida’s 25th congressional district (R) – lost
P. A. Spain
- 1932 – Texas’ at large congressional district (Liberty) – lost
Paul Spain
- 2014 – Florida’s 22nd congressional district (R) – lost
- 2016 – Florida’s 21st congressional district (R) – lost
Hal Spake
- 2006 – Oklahoma’s 4th congressional district (D) – lost
Carla Spalding
- 2016 – Florida’s 18th congressional district (NPA) – lost
- 2020 – Florida’s 23rd congressional district (R) – lost
Joseph Spalletta
- 1992 – New Jersey’s 6th congressional district (The People’s Candidate) – lost
Joseph Spalti
- 1922 – Missouri’s 11th congressional district (SL) – lost
- 1926 – Missouri’s 11th congressional district (S) – lost
- 1930 – Missouri’s 11th congressional district (SL) – lost
Abigail Anne Davis Spanberger
- 2020 – Virginia’s 7th congressional district (D-inc) – won
- 2022 – Virginia’s 7th congressional district (D) – won
Abigail Anne Davis Spanberger
- 2018 – Virginia’s 7th congressional district (D) – won
- 2020 – Virginia’s 7th congressional district (D) – won
Harriet A. Spanel
- 1994 – Washington’s 2nd congressional district (D) – lost
Benjamin J. Spang
- 1934 – Pennsylvania’s 6th congressional district (Prog.) – lost
C. E. (Mayor) Spang
- 1946 – Illinois’ 18th congressional district (D) – lost
- 1956 – Illinois’ 17th congressional district (D) – lost
Donald F. Spang
- 1954 – Pennsylvania’s 14th congressional district (R) – lost
Fred T. Spangler
- 1954 – United States Senate (Texas) (C) – lost
- 1956 – Texas’ at large congressional district (C) – lost
Tom Spangler
- 2014 – Indiana’s 8th congressional district (D) – lost
Joseph A. Spaniolo
- 1974 – Michigan’s 14th congressional district (Labor) – lost
Nancy B. Spannaus
- 1990 – United States Senate (Virginia) (I) – lost
- 2002 – United States Senate (Virginia) (I) – lost
Alexander H. Spano
- 2014 – New Jersey’s 2nd congressional district (D-R) – lost
Vincent Ross Spano
- 2018 – Florida’s 15th congressional district (R) – won
John Jackson Sparkman
- 1936 – Alabama’s 8th congressional district (D) – won
- 1938 – Alabama’s 8th congressional district (D) – won
- 1940 – Alabama’s 8th congressional district (D) – won
- 1942 – Alabama’s 8th congressional district (D) – won
- 1944 – Alabama’s 8th congressional district (D) – won
- 1946 – Alabama’s 8th congressional district (D) – won
- 1946 – United States Senate (Alabama) (Special) (D) – won
- 1948 – United States Senate (Alabama) (D) – won
- 1954 – United States Senate (Alabama) (D) – won
- 1960 – United States Senate (Alabama) (D) – won
- 1966 – United States Senate (Alabama) (D) – won
- 1972 – United States Senate (Alabama) (D) – won
Richard D. Sparkman
- 1980 – Florida’s 10th congressional district (D) – lost
Adam Sparks
- 2000 – California’s 8th congressional district (R) – lost
Arthur L. Sparks
- 1946 – Kansas’ 5th congressional district (D) – lost
Barbara Sparks
- 1976 – Ohio’s 21st congressional district (R) – lost
Bill Sparks
- 1962 – Kansas’ 3rd congressional district (D) – lost
Charles Isaac Sparks
- 1928 – Kansas’ 6th congressional district (R) – won
- 1930 – Kansas’ 6th congressional district (R) – won
- 1932 – Kansas’ 6th congressional district (R) – lost
David Sparks
- 2010 – Texas’ 24th congressional district (L) – lost
Kevin Walker Sparks
- 1982 – Illinois’ 2nd congressional district (R) – lost
Nicholas B. Sparks
- 2008 – Alabama’s 4th congressional district (D) – lost
James M. Sparling, Jr.
- 1974 – Michigan’s 8th congressional district (R) – lost
Victoria Spartz
- 2020 – Indiana’s 5th congressional district (R-inc) – won
- 2022 – Indiana’s 5th congressional district (R) – won
J. E. Spaulding
- 1932 – Virginia’s at large congressional district (R) – lost
Josiah A. Spaulding
- 1970 – United States Senate (Massachusetts) (R) – lost
Lewis D. Spaulding
- 1924 – United States Senate (Illinois) (Com. Land) – lost
Mary B. Spaulding
- 1980 – New York’s 16th congressional district (RTL) – lost
Preston T. Spaulding
- 1996 – Tennessee’s 4th congressional district (I) – lost
Stephany Rose Spaulding
- 2018 – Colorado’s 5th congressional district (D) – lost
Theodore O. Spaulding
- 1950 – Pennsylvania’s 4th congressional district (R) – lost
W. D. Spayne
- 1966 – Texas’ 8th congressional district (R) – lost
John Charles Speaks
- 1920 – Ohio’s 12th congressional district (R) – won
- 1922 – Ohio’s 12th congressional district (R) – won
- 1924 – Ohio’s 12th congressional district (R) – won
- 1926 – Ohio’s 12th congressional district (R) – won
- 1928 – Ohio’s 12th congressional district (R) – won
- 1930 – Ohio’s 12th congressional district (R) – lost
- 1932 – Ohio’s 12th congressional district (R) – lost
- 1934 – Ohio’s 12th congressional district (R) – lost
James Zacharie Spearing
- 1924 – Louisiana’s 2nd congressional district (D) – won
- 1926 – Louisiana’s 2nd congressional district (D) – won
- 1928 – Louisiana’s 2nd congressional district (D) – won
Harry Spears
- 1924 – Tennessee’s 10th congressional district (R) – lost
