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Samm Simpson
- 2006 – Florida’s 10th congressional district (D) – lost
Sidney Elmer Simpson
- 1942 – Illinois’ 20th congressional district (R) – won
- 1944 – Illinois’ 20th congressional district (R) – won
- 1946 – Illinois’ 20th congressional district (R) – won
- 1948 – Illinois’ 20th congressional district (R) – won
- 1950 – Illinois’ 20th congressional district (R) – won
- 1952 – Illinois’ 20th congressional district (R) – won
- 1954 – Illinois’ 20th congressional district (R) – won
- 1956 – Illinois’ 20th congressional district (R) – won
Thomas Simpson
- 1976 – Michigan’s 19th congressional district (Labor) – lost
W. Roger Simpson
- 1948 – Pennsylvania’s 9th congressional district (D) – lost
William T. Simpson
- 1924 – New York’s 5th congressional district (R) – lost
David J. Sims
- 1922 – New York’s 36th congressional district (D) – lost
Floyd E. Sims
- 1972 – California’s 14th congressional district (R) – lost
Hugo Sheridan Sims, Jr.
- 1948 – South Carolina’s 2nd congressional district (D) – won
Joe Sims
- 1958 – Tennessee’s 6th congressional district (R) – lost
Lawrence H. Sims
- 1996 – Michigan’s 5th congressional district (R) – lost
Mike Sims
- 1964 – New Mexico’s at large congressional district (R) – lost
Richard M. Sims
- 1994 – Tennessee’s 3rd congressional district (I) – lost
- 1996 – Tennessee’s 3rd congressional district (I) – lost
- 1998 – Tennessee’s 3rd congressional district (I) – lost
Richard P. Sims
- 2000 – Tennessee’s 7th congressional district (D) – lost
Robert M. Sims
- 1926 – Alabama’s 8th congressional district (R) – lost
Robert R. Sims, Jr.
- 1996 – Texas’ 7th congressional district (I) – lost
Ronald Cordell Sims
- 1994 – United States Senate (Washington) (D) – lost
Joe Sinagra
- 2006 – New Jersey’s 12th congressional district (R) – lost
Richard Sinapi
- 1984 – Rhode Island’s 2nd congressional district (D) – lost
Clifford J. Sinclair
- 1978 – Illinois’ 17th congressional district (D) – lost
Dean L. Sinclair
- 1990 – United States Senate (South Dakota) (I) – lost
James Herbert Sinclair
- 1920 – North Dakota’s 3rd congressional district (R) – won
- 1922 – North Dakota’s 3rd congressional district (R) – won
- 1924 – North Dakota’s 3rd congressional district (R) – won
- 1926 – North Dakota’s 3rd congressional district (R) – won
- 1928 – North Dakota’s 3rd congressional district (R) – won
- 1930 – North Dakota’s 3rd congressional district (R) – won
- 1932 – North Dakota’s at large congressional district (R) – won
- 1934 – North Dakota’s at large congressional district (Prog.) – lost
Kyle Sinclair
- 2022 – Texas’ 20th congressional district (R) – lost
Mary F. Sinclair
- 1994 – Virginia’s 1st congressional district (D) – lost
Suzanne Sinclair
- 2004 – Washington’s 2nd congressional district (R) – lost
Upton Sinclair, Jr.
- 1920 – California’s 10th congressional district (S) – lost
- 1922 – United States Senate (California) (S) – lost
Susan Pendergast Sindt
- 2016 – Minnesota’s 4th congressional district (M) – lost
- 2018 – Minnesota’s 4th congressional district (M) – lost
- 2020 – Minnesota’s 4th congressional district (R) – lost
Kyrsten Lea Sinema
- 2012 – Arizona’s 9th congressional district (D) – won
- 2014 – Arizona’s 9th congressional district (D) – won
- 2016 – Arizona’s 9th congressional district (D) – won
- 2018 – United States Senate (Arizona) (D) – won
James Singer
- 2018 – Utah’s 3rd congressional district (D) – lost
Navraj Singh
- 2008 – California’s 27th congressional district (R) – lost
Shane Singh
- 2005 – California’s 5th congressional district (Special) (R) – lost
Melissa Singler
- 1976 – United States Senate (Ohio) (SW) – lost
Melissa Singler
- 1972 – Texas’ 10th congressional district (SW) – lost
Milo Singler
- 1956 – Wisconsin’s 8th congressional district (D) – lost
- 1958 – Wisconsin’s 8th congressional district (D) – lost
- 1960 – Wisconsin’s 8th congressional district (D) – lost
Britt R. Singletary
- 1980 – Mississippi’s 4th congressional district (D) – lost
La’Ron Singletary
- 2022 – New York’s 25th congressional district (R) – lost
Marilyn M. Singleton
- 2012 – California’s 13th congressional district (NPP) – lost
Rebecca Sink-Burris
- 1998 – United States Senate (Indiana) (L) – lost
- 2010 – United States Senate (Indiana) (L) – lost
Adelaide Alexander Sink
- 2014 – Florida’s 13th congressional district (Special) (D) – lost
Jeff Sinnard
- 2012 – Ohio’s 1st congressional district (D) – lost
George Albert Sinner
- 1964 – North Dakota’s 1st congressional district (D) – lost
George B. Sinner
- 2014 – North Dakota’s at large congressional district (D) – lost
Nicholas John Sinnott
- 1920 – Oregon’s 2nd congressional district (R) – won
- 1922 – Oregon’s 2nd congressional district (R) – won
- 1924 – Oregon’s 2nd congressional district (R) – won
- 1926 – Oregon’s 2nd congressional district (R) – won
Steve Sinton
- 2006 – Georgia’s 6th congressional district (D) – lost
C. Hale Sipe
- 1928 – Pennsylvania’s 26th congressional district (D) – lost
Allen J. Sipher
- 1982 – Michigan’s 18th congressional district (D) – lost
C. J. Sipple
- 1922 – Kentucky’s 11th congressional district (D) – lost
Scott Mills Sipprelle
- 2010 – New Jersey’s 12th congressional district (R) – lost
Joe Sir
- 1958 – Tennessee’s 4th congressional district (W/I) – lost
Albio Sires
- 1986 – New Jersey’s 14th congressional district (R) – lost
- 2006 – New Jersey’s 13th congressional district (D) – won
- 2008 – New Jersey’s 13th congressional district (D) – won
- 2010 – New Jersey’s 13th congressional district (D) – won
- 2012 – New Jersey’s 8th congressional district (D) – won
- 2014 – New Jersey’s 8th congressional district (D) – won
- 2016 – New Jersey’s 8th congressional district (D) – won
- 2018 – New Jersey’s 8th congressional district (D) – won
- 2020 – New Jersey’s 8th congressional district (D) – won
Henry Siroky
- 1920 – Missouri’s 12th congressional district (S) – lost
- 1924 – Missouri’s 12th congressional district (S) – lost
